論文名 | Molecular Epidemiological Study on Passive Smoking and Estrogen Receptor Expression in Never-smokers with Non-small Cell Lung Cancer |
著者名 | |
著者名(別言語) | 吉本, 直樹 / 川口, 知哉 / 伊佐, 俊一 / / 田宮, 朗裕 / 浅井, 一久 / 工藤, 新三 / 平田, 一人 |
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抄録・内容(英) | Background : Although sex hormones are thought to play an important role in the carcinogenesis of non-small cell lung cancer (NSCLC) in never-smokers, the causative mechanism remains unknown. Passive smoking (PS) is common among East Asian women and has been suggested to be a potential cause of the disease. / Methods : We systematically evaluated the expression of estrogen receptor (ER), the prevalence of PS, and genetic mutations using tumor samples from a prospectively registered cohort of never-smokers with lung cancer. The study enrolled 92 never-smokers with NSCLC. Expression of ERα, ERβ, and progesterone receptor (PR) was examined via immunohistochemical staining (IHC). Detailed PS information was obtained through a standardized questionnaire. The cumulative dose of PS (CPS) was evaluated as a sum of the number of exposure years at home and/or in the work place.... |
言語 | eng |
ページ開始 | 77 |
ページ終了 | 84 |
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キーワード(英) | |
著者版フラグ | publisher |
著者所属(英) | Osaka City University / Osaka City University / National Hospital Organization Kinki-Chuo Chest Medical Center / Hyogo Medical Collage / National Hospital Organization Kinki-Chuo Chest Medical Center / Osaka City University / Osaka City University / Osaka City University |
2人目の著者情報 : KAKEN | |
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3人目の著者情報 : KAKEN | |
6人目の著者情報 : KAKEN | |
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7人目の著者情報 : KAKEN | |
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8人目の著者情報 : KAKEN | |
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号 | |
刊行年月 | 2016-12 |
出版社 | OSAKA CITY MEDICAL ASSOCIATION |
ISSN | 0030-6096 |
雑誌書誌ID(NII) | AA00765896 |
大阪市大OPACへのリンク | SB00009780 |
資料種別 | |
資料種別(英語) | Journal Article |
権利 | This article may be downloaded for personal use only. Any other use requires prior permission of the author and Osaka City Medical Association. |