論文名 Switching to tenofovir disoproxil fumarate vs continuing treatment in chronic hepatitis B patients who maintain long-term virological response to entecavir therapy: a randomized trial
記事種別等 RESEARCH ARTICLE
著者名 著者名(別言語) 飯田(上野), 綾子 / 榎本, 大 / 小塚, 立蔵 / 田守, 昭博 / 河田, 則文
本文(PDF) ( 636.2KB) ダウンロード回数:
回
この文献へのリンクには次のURLを使用してください 抄録・内容(英) No controlled trial in patients with chronic hepatitis B virus (HBV) infection on long-term entecavir (ETV) treatment, comparing switching to tenofovir disoproxil fumarate (TDF) with continuing the therapy, has been reported. Twenty-seven nucleos(t)ide-naïve patients with chronic HBV who underwent ETV therapy for ≥5 years and maintained virological response were included and randomized into two groups: one group continued ETV, and the other switched to TDF, in a 1:2 ratio. The primary endpoint was changed from baseline in serum hepatitis B surface antigen (HBsAg) level at week 48. The baseline characteristics were not different between nineteen patients in the TDF group and eight patients in the ETV group. Mean decreases in HBsAg level at week 48 were 0.023 an 0.042 log_10 IU/mL in the TDF and ETV groups, respectively (P = 0.94)....
備考 This research was supported in part by the Program for Basic and Clinical Research on Hepatitis of the Japan Agency for Medical Research and Development, Grant/Award Number: 16fk0210206h0002.
言語 eng
ページ開始 1295
ページ終了 1300
キーワード(日) キーワード(英) 著者版フラグ author
著者所属(英) Osaka City University / Osaka City University / Osaka City University / Osaka City University / Osaka City University
2人目の著者情報 : KAKEN 2人目の著者情報 : その他 3人目の著者情報 : KAKEN 4人目の著者情報 : KAKEN 4人目の著者情報 : その他 5人目の著者情報 : KAKEN 5人目の著者情報 : その他 収録物名 巻 号 刊行年月 2019-07
出版社 Wiley
ISSN 1096-9071
雑誌書誌ID(NII) AA11623598
資料種別 資料種別(英語) Journal Article
DOI https://doi.org/10.1002/jmv.25442
権利 This is the peer reviewed version of the following article: Journal of Medical Virology, Volume91, Issue7, pp.1295-1300., which has been published in final form at https://doi.org/10.1002/jmv.25442 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
異版である