| 論文名 | Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease |
| 著者名 | |
| 著者名（別言語） | 杉山, 由香里 / 浅井, 一久 / 山田, 一宏 / 呉家, 由子 / 井尻, 尚樹 / 渡辺, 徹也 / 金澤, 博 / 平田, 一人 |
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| 抄録・内容（英） | Background: Cigarette smoking-induced oxidant–antioxidant imbalance is a factor that contributes to the pathogenesis of COPD through epithelial cell apoptosis. Irisin is a skeletal muscle cell-derived myokine associated with physical activity. Irisin is also known to decrease oxidant-induced apoptosis in patients with diabetes mellitus. However, the correlation between irisin and emphysema in COPD and its role in epithelial cell apoptosis remains unknown. / Subjects and methods: Forty patients with COPD were enrolled in this study. Pulmonary function tests and measurements of the percentage of low-attenuation area on high-resolution computed tomography images were performed, and the results were evaluated for correlation with serum irisin levels.... |
| 備考 | This work was supported in part by research grants from the Japan Society for the Promotion of Science (JSPS) Kakenhi grant 15K09185 to KA. |
| 言語 | eng |
| ページ開始 | 765 |
| ページ終了 | 772 |
| キーワード（日） | |
| キーワード（英） | |
| 著者版フラグ | publisher |
| 著者所属（英） | Osaka City University / Osaka City University / Osaka City University / Osaka City University / Osaka City University / Osaka City University / Osaka City University / Osaka City University |
| 2人目の著者情報 : KAKEN | |
| 2人目の著者情報 : その他 | |
| 7人目の著者情報 : KAKEN | |
| 7人目の著者情報 : その他 | |
| 8人目の著者情報 : KAKEN | |
| 8人目の著者情報 : その他 | |
| 収録物名 | |
| 巻 | |
| 号 | |
| 刊行年月 | 2017-03-02 |
| 出版社 | Dove Medical Press |
| ISSN | 1176-9106 |
| 雑誌書誌ID（NII) | AA12158595  |
| 資料種別 | |
| 資料種別(英語) | Journal Article |
| DOI | https://doi.org/10.2147/COPD.S126233 |
| 権利 | © 2017 Sugiyama et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
